Best Formula

After you and your trusted health care expert have agreed that L-methyl folate supplementation is correct for you, the following step is to select a dose and a formula. At Methyl-Life Pro, we offer L-methyl folate in five different dosage levels as a standalone product, three dosage levels in combination with our best-selling B-complex vitamin supplement formula, and Vit B-12, Vit B-6, and magnesium are examples of “cofactors,” which are merely Vit B-12, B-6, and magnesium.

What is Methylation and How Does It Work?

Most likely, you’ve opted to start taking L-methyl folate supplements because you have a genetic mutation that affects the methylation process in the majority of your body’s cells. Adding a methyl group to another molecule is known as methylation.

Methylation and demethylation are cellular processes that regulate the fight-or-flight stress response, inflammation, immunological response, energy separation from food, brain chemistry, and hormone, toxin, and heavy metal detoxification. Methylation necessitates the production and recycling of glutathione, the body’s most important antioxidant. Glutathione directly neutralizes free radicals, reduces inflammation, and aids the effectiveness of other antioxidants such as vitamin C, E, and lipoic acid.

What are “Cofactors” for L-Methylfolate, and Do I Need Them?

Because your cells now have access to a supply of the activated form of folate as a methyl donor. Supplementing with L-methyl folate is a beautiful way to improve your body’s ability to methylate effectively. However, L-methyl folate is not the only methylation precursor. B-6, B-12, and magnesium are the required cofactors for folate given by this formula.

Homocysteine levels in the blood can rise if vitamin B-6 is deficient, as B-6 aids in the synthesis of glutathione from homocysteine. A B-12 deficiency, which prevents homocysteine from being converted to methionine, will bring the cycle to a halt. L-methyl folate and B-12 are essentially coenzymes in the folate methylation process. The primary remethylation route is catalyzed by methionine synthase, which is supported by vitamin B-12 and activated folic acid (L-methyl folate).

As a result of insufficient or dysregulated neurotransmitter production, many patients who have had folate deficiency due to genetic abnormalities have also experienced mood instability. Once the methylation cycle is stabilized with supplementation, adequate magnesium levels will become increasingly important. The body and brain must deal with the increased number of neurotransmitters.

Of all, this is only one of many advantages to taking a magnesium supplement.

Why use a B-Complex instead of the cofactors if the cofactors cover methylation?

Except for vitamin C, the B-complex refers to all of the known essential water-soluble vitamins. The proper biological activity of B-vitamins is required throughout the body. B-6, B-12, and B-9 (folate) are all vitamins that are well-known for their health benefits. For energy metabolism, the vitamins B-1 (thiamin), B-2 (riboflavin), and B-3 (niacin) are all required. Vitamin B-1 is good for your brain, while vitamin B-2 is good for your eyesight. B-3 helps with digestion and maintains a healthy appetite.

Although B-vitamins are water-soluble and non-toxic, you must get enough of them to meet your metabolic needs. Before making an informed decision, please discuss these alternatives with a trusted health care practitioner.

References

1. Corey, Michelle. “Methylation: Why It Matters For Your Immunity, Inflammation & More”. MBG Food. Accessed
2. Audhya, Tapan. “Role of B Vitamins in Biological Methylation.” Health Diagnostics and Research Institute (2012): 1-20.
3. Greenblatt, James.” Magnesium: The Missing Link in Mental Health.” Integrated Medicine for Mental Health.
4. Heitz, David. “Symptoms of Vitamin B Deficiency.” Healthline. December 10, 2016. 
5. Hrefna Palsdottir,What are the health benefits of biotin?
6. NIH. Pantothenic Acid Fact Sheet for Health Professionals. NIH Office of Dietary Supplements.
7. Aviv, Alex, Daniel Levy, and R. H. Belmaker. “Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder.” Am J Psychiatry 152 (1995): 1084-1086.
8. Saltiel, Alan R. “Second messengers of insulin action.” Diabetes care 13.3 (1990): 244-256.
9. NIH. CholineFact Sheet for Health Professionals. NIH Office of Dietary Supplements. Accessed
10. Kaneko, Jiro Jerry, John W. Harvey, and Michael L. Bruss, eds. Clinical biochemistry of domestic animals. Academic press, 2008.

Sebastian

Sebastian was born and raised in the busy city of Abbottabad. As a journalist, Saad Mushtaq has contributed to many online publications including the PAK Today and the Huffing Post. In regards to academics, Saad Mushtaq earned a degree in business from the Abbottabad UST, Havelian. Saad Mushtaq follows the money and covers all aspects of emerging tech here at The Hear Up.Thanks