Connect with us

HEALTH

Selective Androgen Receptor Modulators (SARMs)

Published

on

SARMS

Androgenic therapy with injectable, oral and more recent transdermal drugs has been available to doctors for many years to treat a variety of male diseases. To a lesser extent, its application has been extended to some female indications. Unlike female sex hormone therapies, which are widely used and widely used in the field of hormone replacement, reproductive disorders, gynecological cancers and contraception, androgen therapy is not widely used. Recent progress has clearly demonstrated that androgen therapy will undergo a major change, both in the scope and in the range of applications that can benefit from this upcoming progress.

Various factors contributed to this change. First, the significant advances in hormonal replacement therapy (HRT) in postmenopausal women and the extension and application of HRT for the treatment and prevention of serious diseases such as osteoporosis, cardiovascular disease, breast cancer, mood and cognition, have clearly demonstrated value in new HRT therapies to improve women’s health (2-4) and extrapolation emphasize the potential for similar approaches to the treatment of men’s health problems.

Second, the development and commercialization of new selective estrogen receptor modulators (SERMs) has provided both pre-clinical and clinical evidence that we can develop molecules with high levels of tissue selectivity targeting the estrogen receptor to eliminate and maintain unwanted side effects (and future). to improve the positive, protective effects of selective transcriptional receptor activation (3-7).

Third, major advances in our understanding of the activation and function of nuclear receptors have laid the molecular foundation for new drug development efforts to develop a new generation of tissue-selective molecules that target steroid and other nuclear receptors. The proof-of-concept of tissue selectivity has now been extended to many compounds that interact with different nuclear receptors such as: Estrogen (ER), progesterone (PR), androgen (AR), retinoid (RAR / RXR) and peroxisome proliferation, including activated receptors (PPARs) (6-11).

With the information described above, we were able to register a developmental trajectory and to profile the desired activity and selective indications for a new class of molecules focused on the androgen receptor. In the following we briefly describe the molecular mechanisms that underlie the potential for selective modulation of AR by different ligands, and the possibilities offered by new SARMs for therapies for broad and selective applications of androgen therapy in both men and women.

Molecular progress in the structure and function of AR: a key to releasing tissue selectivity

The AR is a transcription factor and belongs to the extensive family of nuclear receptors. As such, it shares substantial structure homology with the other members of the family, including specific protein subdomains that activate or suppress gene activity. These different mechanisms contribute to the combinatorial recruitment and activity of coactivators and co-depressors to enable selective regulation of individual genes in certain tissues by the AR.

Since different ligands can provide a variety of different combinatorial transcriptional regimens in different tissues and cells, the development of SARMsToday with intrinsic partial agonistic activity offers a unique opportunity to develop new therapeutics with different activity profiles.

The different sets of molecules contain individual members who have selective preferences for specific tissues or activities (e.g., Trophic in muscles, strong or very weak gonadotropin feedback) and very different activity ratios in sexual accessory tissues (prostate, seminal vesicles) compared to other peripheral tissues (ie muscles) or central

Role of SARMs in Androgen Therapy for Men

Currently used androgenic replacement therapy formulations are broadly limited to injectable or testosterone or testosterone ester skin release formulations. Commercially available injectable forms of testosterone esters (such as testosterone anthogenate, propionate or cypionate) cause unwanted fluctuations in testosterone blood levels with supraphysiological concentrations at an early stage and subnormal levels towards the end of the period prior to the next injection, resulting in an unsatisfactory profile and in some cases unwanted side effects.

Although dermal patches offer a better testosterone blood profile, skin irritation and daily use limit the benefit and acceptance of this type of therapy (1, 20-22). Oral preparations such as fluoxymesterone and 17α-methyltestosterone are not currently used because there are concerns about liver toxicity associated with the 17α-alkyl group and their efficacy is slightly lower. Therefore, these compounds are considered outdated (1, 20) and do not represent a viable form of therapy.

The discovery and development of SARMs offers the possibility to design molecules that are not only orally active, but focus on AR in different tissues to induce the desired activity for each of the most important indications that benefit from androgen therapy. The desired activity profile of new SARMs is described in Table 1. For simplicity, we have listed the desired activity in tissues or specific parameters for a specific indication (i.e., male hypogonadism) in addition to a category for selected indications. The latter offers a series of choices for the design of molecules that can respond to specific needs in the treatment of various diseases.

Therefore, we imagine that an ideal SARM for the treatment of primary or secondary male hypogonadism (Table 1) has the following profile: orally active, ideally with a pharmacokinetic profile consistent with once-daily administration and stimulating prostate and seminal vesicles. and other canned sexual accessory tissues corresponding to those required to increase muscle mass and strength and lean body mass, to promote bone growth and to maintain/restore libido, virilization and male habit.

Advertisement

HEALTH

How Efficient Is PRP Therapy for Chronic Pain?

Published

on

How Efficient Is PRP Therapy for Chronic Pain?

Lingering, debilitating, chronic pain has a cascade impact on your body and everyday life. To relieve pain, most patients and their physicians have resorted to opioid drugs, but the remedy has done more harm than good. Since the late 1990s, when drug manufacturers convinced doctors that opioids had no addictive properties, over 2M persons have become hooked on these painkillers, and almost 48,000 opioid-related overdose fatalities have been recorded. That statistic accounts for about 130 person’s daily, and the numbers do not seem to stop soon, but instead are rising even higher. Whereas drugs, when properly supplied and used, have a position in pain management, Dr. Garen Gajian of Pain & Anesthesia Care takes a different approach. Whenever possible, Dr. Gajian chooses interventional techniques that combine cutting-edge technology, nonpharmacological paths, and innovative procedures. One such effective technique is PRP therapy. Read on to discover how effective New Brunswick PRP Therapy is in addressing chronic pain.

How Does Your Body Deal With Pain?

When you get hurt, your body goes into self-healing mode and releases platelet cells to the wounded location right away. These platelet cells include important healing and growth factors that help to repair injured tissues. Moreover, these platelets call on stem cells within your body to help complete the healing process and alleviate swelling and discomfort.

How Does PRP Improve Your Body’s Pain-Relieving Capabilities?

Generally, PRP is a contemporary therapy that aids in the relief of pain by boosting your body’s natural healing mechanism. PRP operates much like your body’s own systems; it packs the wounded area with those all-essential platelets, while also speeding up the healing process by delivering the platelets to the targeted area quicker and in greater concentrations.

Dr. Gajian begins by extracting a small blood sample from your arm, just like any standard check-up. He then spins your blood at increased speeds in a centrifuge, separating blood rich in platelets from blood with low platelet quantities. After that, he uses a syringe to deliver the platelet-rich plasma blood to the wounded region, which is the root of your chronic pain. Now, all that is left is to wait for the platelets to do what they do best: neutralize your agony and start healing.

What Types Of Pain Does PRP Help With?

As PRP keeps providing immediate and lasting pain relief for various conditions, more applications are being discovered. Nonetheless, some of the conditions PRP therapy has proven effective with include:

§  ACL injuries

§  Sprained ligaments

§  Ankle sprains

§  Rotator cuff injuries

§  Plantar fasciitis

§  Osteoarthritis pain

§  Tendonitis

§  Arthritis

§  Back injuries

§  Spinal injuries

§  Neck injuries

§  Tennis elbow

§  Disc herniation

§  Post-surgical wounds

How Safe Is PRP Therapy?

The safety of PRP is maybe its most significant feature. PRP utilizes your blood; hence, there is virtually minimal chance of rejection and infection. Besides, there is very little downtime to deal with. Only a needle injection to draw the blood and inject the platelets is needed; hence, you can resume your schedule right away.

How Efficient Is PRP?

Everybody reacts to PRP in their unique way. Most persons enjoy instant pain alleviation and complete recovery within several weeks or months. As your body reacts to the treatment and your stem cells begin to regenerate, you should notice a considerable reduction in your pain.  

More significantly, platelet-rich plasma strives to repair the inherent problem that has been triggering your chronic pain to continue to live free of pain.

Ultimately, PRP therapy has numerous advantages over other standard pain relief procedures. Not only will you enjoy an accelerated healing process and reduced downtime, but also minimal post-procedure complications and enhanced mobility. To explore the benefits of this revolutionary pain solution and establish if it could work for you, call the Pain & Anesthesia Care office in New Brunswick, NJ office or book an appointment online today.

Continue Reading

HEALTH

 Effective Remedies for the Flu and Strep Throat Infections

Published

on

 Effective Remedies for the Flu and Strep Throat Infections

Having a runny nose might seem irritating and cause discomfort, and in the case of children, it may be tougher to handle the condition. This situation may bother you, but there are available flu & strep Sugar Land treatments to help you or your child recover from the infections and leave you feeling healthy again.

What is the difference between the flu and strep throat?

The flu is also known as influenza, an infection that affects your respiratory system; lungs, throat, and nose. The influenza virus transmits through tiny airdrops if a person who has the flu sneezes or coughs around you. Strep throat is an infection that causes scratchy, raspy, and itchy throat. The condition stems from a bacterium, Streptococcus pyogenes, a very highly transmissible bacteria. Strep throat is spread when droplets from a person who has the infection sneeze or cough. Surfaces with bacteria can also be a source of infection.

What are the symptoms of flu and strep throat?

Both infections can affect all ages, so if you or your loved one develop the following symptoms, you should visit your doctor. The symptoms may be:

·                     Sore throat

·                     Fever

·                     Swollen tonsils

·                     Headache

·                     Stuffy nose

You may also develop the symptoms but not have strep throat. The flu may feel a lot more like a common cold in its initial stages, but the flu comes on suddenly. The flu also feels much worse than a cold. If strep throat is not treated, it can lead to further complications like rheumatic fever or inflammation in the kidney. If the symptoms start worsening, you develop chest pains, seizures, or difficulty breathing; you should get immediate medical care.

How are flu and strep throat treated?

Your doctor may first have to conduct a comprehensive physical examination through tests to check for flu symptoms or strep throat. Both infections can use the Polymerase Chain Reaction (PCR) test because the test is quick to spot the strains of the infections. Your doctor may also request a COVID-19 test to rule out its possibility. If you happen to have any of the infections, you will need to start treatment. Your doctor may give you painkillers and antibiotics to help reduce the symptoms and lower the risk of spread. If your doctor says the infection is severe, you may have to take an antiviral to help you recover from the flu. You should take the medication with food to reduce nausea and vomiting. You may also adopt some remedies at home like:

·                     Drinking plenty of liquids to avoid dehydration and keep your throat moist

·                     Get enough rest to help your body fight off the infection

·                     Use honey to soothe your throat. But do not give honey if your child is younger than a year.

·                     Gargling with salty water

After a few days, you should feel better in your throat, and you should take your total dosage. Seek emergency services if you see no improvement after two days of medication.

If you suspect you have the flu or strep throat, visit St. Michael’s Elite Hospital to find out more about the infection, get proper treatment, or book your appointment online.

Continue Reading

HEALTH

Effective Treatments for Managing Chronic Kidney Disease

Published

on

Effective Treatments for Managing Chronic Kidney Disease

Kidney disease is a medical condition requiring urgent attention to prevent further progression. There is a chance that you can get an early diagnosis and treatment before it develops into chronic kidney disease or even further to kidney failure. Tsegaw E Egziti M.D is a specialized doctor who can help you create a treatment plan and manage your condition.

What is kidney disease?

Kidney disease is a chronic disease that gradually involves the kidney’s malfunctioning. There are two kidneys in the human body, and they are responsible for the filtration and elimination of waste products from the blood, disposing of them through urine. Therefore if your kidney is not working correctly, they may be unable to filter and control your blood pressure accurately. Chronic kidney disease may always begin without detectable signs and may develop into a final stage failure, a fatal state if dialysis is not done, or even a kidney transplant. You may have to be on treatments for the rest of your life if you develop chronic kidney disease. But there are treatments available for managing your symptoms.

What are the signs and symptoms of kidney disease?

The signs and symptoms may develop gradually as the damage increases slowly. This damage may cause your body to build up waste or fluid and cause problems. The severity of the loss of function may cause signs and symptoms such as:

·                     Nausea and vomiting

·                     Fatigue

·                     Little or frequent urination

·                     Swollen feet

·                     High blood pressure

You may develop other signs and symptoms as the disease progresses, and you must see a doctor. An early diagnosis may prevent further progression of the disease to kidney failure.

What are the available treatments for kidney disease?

Your doctor may first have to carry out a comprehensive evaluation and run tests to determine the severity of your condition. Once the diagnosis is through, your doctor will recommend the proper treatment for you. These treatments may include:

·                     Medications

Your doctor may recommend particular drugs to help control the complications and make your life comfortable. There may be medications to lower blood pressure, lower cholesterol levels, and reduce swelling. These medications will help increase kidney function.

You may develop a final stage kidney disease, and this may require other forms of treatment such as:

·                     Dialysis

It is an artificial removal of waste products and fluid from the blood when your kidney fails to perform. If it is hemodialysis, a machine will filter excess fluid and waste products from your body. Your doctor may pass a tube through your belly and fill your cavity with a solution to absorb the waste and liquid. Later, the solution drains from the body with the debris alongside.

·                     Kidney transplant

Your doctor may recommend surgical removal of your kidney and replacing it with a healthy one. A healthy transplant comes from a donor or the deceased. Once you have a successful transplant, you may need regular medications to prevent your body from declining the new kidney.

Find out more about kidney disease and treatments at Houston Kidney Specialists Center or visit the website to request your appointment.

Continue Reading

Trending