Females usually detect hair loss faster than men, but baldness or alopecia is more common in males due to their hormonal profile. Testosterone has a significant role in male pattern baldness because this hormone is transformed into DHT in the hair follicle, and DHT causes destruction of this structure in the scalp. If you no longer have hair follicles because they are destroyed, you end up with alopecia, and your hair won’t grow back again.
That’s why alopecia is more common in males with bald parents, uncles, or grandparents. It has a genetic predisposition to it, but there’s something we can do to solve the problem. As you will see in this article, ketoconazole, an antifungal agent, is also useful for some cases of alopecia, especially androgenetic alopecia.
Androgenetic alopecia and ketoconazole
Androgenetic alopecia is the most common cause of hair loss in males. It causes a male pattern baldness, which affects the midfrontal and frontoparietal scalp. As it advances, it goes up to the superior portion of the scalp, and it is more common in older Caucasians. It is estimated that around 50% of Caucasian males will develop a form of androgenic alopecia when they reach 50 years old. However, even though genetics are essential, several environmental factors play an important role, including stress, smoking, and consumption of alcohol.
What happens is that circulating testosterone is converted into an active form called DHT or dihydrotestosterone. This hormone binds to their receptors in the scalp, and trigger a dysfunction and later destruction of the hair follicles.
So far, the only treatment approved by the FDA includes oral finasteride and topical minoxidil. This combination is useful to prevent the conversion into DHT and stimulate hair growth, respectively. However, it is not very useful for some patients, and others may develop adverse effects. That is why other therapies have been implemented, including laser light therapy, dutasteride, platelet-rich plasma, hair transplants, and topical ketoconazole.
Ketoconazole is an antifungal agent included in the group of imidazole substances. It inhibits the synthesis of ergosterol, a material that is found in the cell membrane of fungi. But besides its antifungal properties, it is also an anti-inflammatory that inhibits an enzyme called 5-lipooxygenase and blocks the synthesis of testosterone and the concentration of DHT. As such, ketoconazole is another potential treatment of androgenetic alopecia, and it has been studied in animals and humans with promising results.
Is ketoconazole useful to promote hair growth?
According to studies, ketoconazole can be useful in promoting hair growth in patients with androgenetic alopecia. For example, in one of them, the researchers used a ketoconazole lotion, which was meant to be used daily for one year. During the follow-ups, patients who used ketoconazole showed an improvement and significant hair regrowth. Still, according to this study, they needed to wait for a long time to start seeing results.
Other studies evaluated using a ketoconazole shampoo along with 1 mg oral finasteride. The control group included one with oral finasteride alone and another with oral finasteride and 2% minoxidil twice a day. In combination with finasteride, ketoconazole works even better, and the patients had a significant improvement in their condition. Combined treatment was more useful than finasteride alone, and no side effects were reported. However, there was no significant difference between ketoconazole and minoxidil as a side treatment. As such, it is considered a suitable alternative to minoxidil in these patients.
And one of the first studies of ketoconazole for hair loss showed that treating patients with ketoconazole shampoo can lead to potential hair regrowth after 6 months, which increases as the treatment continues and plateaus after one year and 3 months. In comparison, patients who used shampoo with no medication at all remained stable and sometimes experienced a significant increase in the severity of their condition.
Should you choose to use a shampoo with ketoconozale, we recommend Hair Restoration Laboratories’ Professional Strength Hair Restore Shampoo. It contains 1% ketoconozale along with numerous other ingredients that have been clinically proven to help prevent hair loss and promote hair growth.
The present and future of ketoconazole treatment for alopecia
Currently, androgenetic alopecia is a health problem with significant psycho social consequences, and there is a need of established and alternative therapies for these patients. The clinical studies and animal research about ketoconazole for the treatment of alopecia always support its use in some way.
The application of this alternative can be useful in patients with androgenetic alopecia and concomitant seborrheic dermatitis, primarily because ketoconazole has been described as a useful therapy against Malassezia infections. It can also be a safe alternative for women with androgenetic alopecia who are unable to use finasteride treatment or display limited results with minoxidil.
Still, to study ketoconazole in the treatment of androgenic alopecia, we still need more large-scale prospective studies to figure out the exact mechanisms by which ketoconazole promotes hair regrowth. In any case, the absence of side effects of topical ketoconazole makes it a useful candidate to use as an adjunctive therapy to treat male and female patients with androgenetic alopecia, and well designed, and large-scale studies are still necessary to evaluate its efficacy on the long-term.
Saad Mushtaq was born and raised in the busy city of Memphis. As a journalist, Saad Mushtaq has contributed to many online publications including the USA Today and the Huffing Post. In regards to academics, Saad Mushtaq earned a degree in business from the University Of Texas and an master’s degree from the University of Tennessee. Saad Mushtaq follows the money and covers all aspects of emerging tech here at The Hear Up.Thanks
The facial routine and the care that your skin needs this winter
Care that your skin needs this winter
Skin; when winter comes, we all notice that our skin is much more sensitive and drier, so if we want it to remain in perfect condition, it is necessary to follow specific care to protect it and provide it with the nutrition and hydration it needs. Having a proper facial routine is an essential aspect to achieve this. It is not enough to apply a moisturizer any day to care for the skin, but it is convenient to choose very carefully the products that we are going to use since we could cause a few unwanted effects or produce an imbalance in our skin.
So that we can get the most appropriate facial care, Douglas offers us the best brands in cosmetic treatments. In addition, with the Douglas Coupon, you will have the opportunity to access the best discounts to take care of your skin.
Discover how to take care of your skin daily with the most suitable cosmetic products
First of all, one of the steps that we should never skip is sun protection. Although many people still think that sun protection is only for the summer, the truth is that the sun can cause damage to our skin throughout the year, and therefore good foot care cannot be complete without it. Using the correct sunscreen, we will avoid the premature appearance of wrinkles, sun spots, and other skin problems.
La Roche Posay offers us a complete catalog of sunscreens for all skin types, with the best guarantees. We can find from sun creams with SPF 30, up to 50+, with a touch of color, in spray cream or as an Invisible anti-glare facial mist, so that everyone can find the protector that best suits their needs.
Another essential step in any facial routine is cleaning. Dirt can accumulate on the skin if we do not clean it daily, as well as dead cells, which can prevent adequate oxygenation and regeneration of the skin. Therefore, it is recommended to use a good facial cleanser every day, such as Lancome cleansing foams and lotions. In addition to daily cleaning, if we do an in-depth cleaning once a week or every 15 days, with exfoliation included, our skin will thank us. The facial cleansers Foreo can become the perfect complement to it.
The hydration is another essential step in any facial routine. We all know that hydrating the skin is very important, but the reality is that few people hydrate it correctly. First of all, it is essential to choose a good moisturizer, which is suitable for our specific skin type.
To cope with inclement weather and protect ourselves, we must not stop using our moisturizer every morning, and of course, it must have a pleasant, light texture and with the specific benefits that your skin needs, such as anti-wrinkle action, an extra of luminosity or nutrition.
Kora Organics, an exclusive brand in Douglas, has the necessary products to achieve deep hydration. Another of the star brands in terms of hydration is Biotherm. At Douglas perfumerías, we find a varied selection of brand facial creams, masks, and oils, specific for normal, combination, dry skin, or for the most sensitive skin.
Don’t forget to protect your skin this winter and find your ideal facial routine with the most suitable products. In Douglas, you have a varied range of cosmetics from the best brands on the market. Take care and protect your skin this winter.
Although it will be difficult to avoid 100% the effect of cold, there are certain circumstances that can help avoid discomfort. Prevention will be especially necessary for people who have a predisposition to dry skin or who have conditions such as atopic dermatitis.
Brief history of cancer
Commonly identified as a disease of modern life, cancer has accompanied and threatened man since ancient times. Attempts to defeat it largely shaped the history of human and scientific progress (and failures) in the face of disease. From early Egyptian and Greek physicians to aseptic genetics labs, through medieval operations, Victorian operating rooms, the discovery of anesthesia and X-rays, the monumental and award-winning volume.
The Emperor of All Evils by oncologist Siddartha Mukherjee, is a sensitive and intelligent approach to the history of this disease today crossed by marketing, media, laboratory businesses, to which the United States came to declare war on and which we are only now beginning to understand.
In 2010, some 600,000 Americans, and more than 7 million people worldwide died of cancer. In the United States, one in three women and one in two men will develop cancer during their lifetime. A quarter of American deaths, and about 15 percent of all deaths in the world, will be attributed to him. ” These overwhelming numbers are the gateway to one of the 2011 publishing successes.
Winner of the Pulitzer and The Guardian’s First Book Award, nominated for the National Book Critics Circle Award and Top 10 of the year by a critical spectrum as broad as The The New York Times, Time magazine and Oprah Winfrey, The Emperor of All Evils is presented as nothing more and nothing less than the official biography of cancer.
Written between 5 and 15 minutes per day (what was left of free time to its now-famous author, but then respected and young full-time oncologist, more father of the family, Siddartha Mukherjee), the book has almost 700 pages and got contract when his deed went roughly in half. Of course, with Monday’s newspaper, the first thing you think is that it is incredible that the editors have not dueled for publishing it. But the truth is that its author ran into rather mixed thoughts where caution prevailed. “The responses were bipolar.
Or they would say, ‘No one is going to read about cancer,’ or, ‘How could this book not have been written before.’ ” What they all definitely agreed on was that cancer frightens, which only fueled the enthusiasm of its author. “For me, that was the wrong answer. If people are afraid, it is the main reason to speak, “he said emphatically, rounding up his ambitious project.
BRIEF HISTORY OF A LONG FIGHT
It was from the first autopsy that Galen’s theories began to collapse. There was no black bile but an organism to discover. The study of anatomy took up the idea of surgical ablation of cancer, inaugurating an entire stage as prolific as it was bloody, recently alleviated by the discovery of anesthesia in 1846. “Anesthesia and antisepsis were combined technological advances that liberated surgery from its medieval chrysalis.
Armed with ether and carbon dioxide, a new generation of surgeons undertook terribly complex anatomical procedures. ” The adventurous first oncologists managed to remove some tumors from the body, but they could not prevent cancer from growing again sooner or later. Again and again “they went back to the operating table and cut,
The therapeutic frenzy to end the evil crab had its greatest exponent in William Halsted: a cocaine-addicted doctor who invented a radical mastectomy in the late 1800s. Empty the women’s body as much as possible (removing glands, muscles, even rib bones) in order to achieve total remissions and, in many cases, where it was not necessary to operate, with the sinister intention of bending their character.
The surgeries were quite a spectacle. The 1900s inaugurated the era of celebrity medical “trustworthy” who operated to the delight of witnesses as privileged as they were intrigued. “The operating room was for them a theater of operations and surgery, an elaborate performance, often witnessed by a silent audience watching from a skylight above the theater.”
Dazzled by their own brilliance, they could not even see yet the failure of the brutal operation. It was that no matter how much they removed, cancer returned or was already waiting, crouched, in some other organ.
Around the same time, in a different setting, a series of coincidences gave rise to the discoveries of X-rays, radio, and finally, eureka, the crazy idea that this new form of energy might be useful for all this. It was a young man of twenty-one, Emil Grubbe, who on instinct made the first successful test: “Grubbe began to bombard Rose Lee, an older woman affected with breast cancer, by means of an improvised X-ray tube ( …) He irradiated it for 18 days.
Although painful, the treatment had some success. ” Gruebbe immediately followed up with other patients, all with the same result: the tumors were shrinking. At the beginning of the 20th century “a new branch of cancer medicine was born, radiation oncology.”
Are weight loss supplements effective? A burn fat fast review
Weight loss has become a global issue in the present times. At least one person out of three is in search of a magic formula that trims his figure down. Although many companies claim that their weight loss formula can do magic upon just single consumption. But the market is full of frauds and people who are desperate to get slimmer get fooled as well.
Finding one definite solution for all weight problems is quite a tacky task. We might all know people who have been feeling down just because of their weight issues and can not wait to find the solution that works fast. But let us be real, finding fat loss supplements is like risking your health for the sake of a slim figure.
Companies are grabbing a lot of money from teens and even elderly people by showing them dreams of losing fat in the count of days. But let us tell you that as you have reached bellyfatflusher.com, all your weight problems are now upon us. We are here to offer you definite solutions to obesity and fat issues that you might have been carrying from years. Now it’s time to stop spending money on other medications and trust a company that doesn’t only want to sell its goods but wants to see its customers having slim figures.
We understand that many of you might already be disappointed as hell and would have lost hope of having a slim body that’s equally youthful. But we claim the results of our fat, reducing supplements with extreme confidence. Our level of confidence makes us offer our customers a 60-day money-back guarantee as well.
We are assured of the results that will be visible once you take our supplements with faith. Our money-back guarantee is just o show our clients how much effort and knowledge we have put in coming up with this fat loss supplement. We want everyone to try us for once as we are here to give you all the money back if our product fails you at any point in 60 days.
Our fat loss formula isn’t at all hard to consume. We suggest you to keep the equation of 5oz of water + Burn Fat Fast Supplement = Slimmer figure, smaller belly! No hard rules and no googling up the whole regime of consuming a supplement. Neither would you have to overhaul yourself to burn those carbs hanging around your body.
We believe that people of present times are busy and can not spare time for complex medical subscriptions; hence we have retained the simplicity of consuming the Burn Fat Fast Supplement by just mixing it in an amount of water.
Our customers have called the effects of our supplements as magic. The unbelievable turn out of positive results makes them come back to us and tell us their fat loss story. We love hearing from them, and we show authentic feedback to the rest of the customers we get. The reason our fat loss supplement gives such results is that we are completely natural. We do not believe in harming the health of our worthy customers by using anything unnatural for faster results. We maintain our standards and don’t let any unnatural ingredients get passed into our fat loss supplements.
Our Burn Fat Fast Supplement is natural and contains only herbs, few spices, and a controlled amount of amino acids that are there on scientific grounds. We put a safe measure of all these
ingredients in our fat loss supplement and don’t let anything exceed the limit. The consumption of our fat loss supplement leaves the consumer in a better mood. It does not disrupt the digestive system and maintains the acidic levels of the stomach.
Our weight loss supplement has 22 ingredients in total, which perform three actions:
- Help in the detoxication of the body
- Limit the appetite of the consumer
- Provide a healthy weight reduction
The prescribed consumption of this supplement is only two capsules per day. It is suggested that you take these capsules about half an hour before having meals to get better results. It will be a perfect routine if you take one before breakfast and the other before diner. You can easily fit in the consumption of these supplements into your daily routine without any hassle or ‘phone reminder.’
Though we are selling a fat loss product, we also want to educate our consumers. We want you all to know about a chemical that isn’t talked much about but which exits mostly in everything – the ECDs. Fully known as the endocrine-disrupting chemicals. They are the sole cause of disruption in how your body works. Many things that we call safe or inert have a good amount of ECDs in them.
We want you guys to keep an eye on ingredients of things you consume and take note of many ECD’s you are consuming per meal. As far as the results of Burn Fat Fast Supplements are considered, we claim that you wouldn’t be coming back to us getting your back. Instead, you will come to get more pills as your weight loss journey with us was a success!
Many people think that the initial results that these supplements show are just an impression, and the second week will bring their previous weight back on numbers. But our supplement is different! It gives you continuous non-reversing results. Your weight, once gone, is gone forever. Unless you don’t return to unhealthy lifestyles and don’t take the fat loss supplements we provide.
We see many diet routines telling you to g to extremes and cut off all the food supplements that are essential for having a healthy body. But the good news is that with fat loss supplements you get from bellyfatflusher.com, you wouldn’t have to cut off any of your favorite snacks. Though overconsumption is not suggested, you can keep eating the snacks you like and still not worry about your weight.
We won’t suggest you to completely rely on the supplements and expect great results. You will have to have a look at your lifestyle and cut off the things that add extra toxicity to your life. Including the ECDs we mentioned above, you will have to drop things that are bluntly the cause of your poor health. Just drop anything unnecessary and stay loyal to your fat loss supplement consumption, and the results are not that far already!
Our fat loss supplement will give you the physique that many of you never had. Many people face obesity from the early years of their childhoods and never get able to get rid of it in later life. But as we are here to help you out of weight issues, so worry no more. You might now want to have the pills that are like magic. Try for yourself and see if it works. And if it doesn’t suit you and doesn’t give you the required results, then come and have all your money back within sixty days. We are sure that you would be thankful for the day when you happened to come across bellyfatflusher.com.
Our supplements have made many of our customers happy to the core, and nothing brings us more joy than seeing them sharing their new vs. old photos! The pure joy and beaming happiness on their faces encourage us to keep working harder and keep supplying the best products to the world.
Let your bodies experience the positive change that it has been waiting for for ages. Let us be the providers of this pure happiness of having a lovely physique. We would love our fat loss supplements to be named as the happy pills based upon the definite positive results they are going to give to every one of you.
Let’s get rid of that years-old belly fat that stopping you from wearing your favorite summer suit. Or that’s stopping you from having a fun day at the beach! Let’s combat the fat together! Contact us today and be sure of the slim figure and flat belly that you deserve to enjoy!
Umar Nisar was born and raised in the busy city of Tennessee. As a journalist, Umar Nisar has contributed to many online publications including USA Today and the Huffing Post. In regards to academics, Umar Nisar earned a degree in business from the University Of Texas and a master’s degree from the University of Tennessee. Umar Nisar follows the money and covers all aspects of emerging tech here at The Hear Up.
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