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Is ketoconazole useful to prevent hair loss?

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Is ketoconazole useful to prevent hair loss?

Females usually detect hair loss faster than men, but baldness or alopecia is more common in males due to their hormonal profile. Testosterone has a significant role in male pattern baldness because this hormone is transformed into DHT in the hair follicle, and DHT causes destruction of this structure in the scalp. If you no longer have hair follicles because they are destroyed, you end up with alopecia, and your hair won’t grow back again.

That’s why alopecia is more common in males with bald parents, uncles, or grandparents. It has a genetic predisposition to it, but there’s something we can do to solve the problem. As you will see in this article, ketoconazole, an antifungal agent, is also useful for some cases of alopecia, especially androgenetic alopecia.

Androgenetic alopecia and ketoconazole

Androgenetic alopecia is the most common cause of hair loss in males. It causes a male pattern baldness, which affects the midfrontal and frontoparietal scalp. As it advances, it goes up to the superior portion of the scalp, and it is more common in older Caucasians. It is estimated that around 50% of Caucasian males will develop a form of androgenic alopecia when they reach 50 years old. However, even though genetics are essential, several environmental factors play an important role, including stress, smoking, and consumption of alcohol.

What happens is that circulating testosterone is converted into an active form called DHT or dihydrotestosterone. This hormone binds to their receptors in the scalp, and trigger a dysfunction and later destruction of the hair follicles.

So far, the only treatment approved by the FDA includes oral finasteride and topical minoxidil. This combination is useful to prevent the conversion into DHT and stimulate hair growth, respectively. However, it is not very useful for some patients, and others may develop adverse effects. That is why other therapies have been implemented, including laser light therapy, dutasteride, platelet-rich plasma, hair transplants, and topical ketoconazole.

Ketoconazole is an antifungal agent included in the group of imidazole substances. It inhibits the synthesis of ergosterol, a material that is found in the cell membrane of fungi. But besides its antifungal properties, it is also an anti-inflammatory that inhibits an enzyme called 5-lipooxygenase and blocks the synthesis of testosterone and the concentration of DHT. As such, ketoconazole is another potential treatment of androgenetic alopecia, and it has been studied in animals and humans with promising results.

Is ketoconazole useful to promote hair growth?

According to studies, ketoconazole can be useful in promoting hair growth in patients with androgenetic alopecia. For example, in one of them, the researchers used a ketoconazole lotion, which was meant to be used daily for one year. During the follow-ups, patients who used ketoconazole showed an improvement and significant hair regrowth. Still, according to this study, they needed to wait for a long time to start seeing results.

Other studies evaluated using a ketoconazole shampoo along with 1 mg oral finasteride. The control group included one with oral finasteride alone and another with oral finasteride and 2% minoxidil twice a day. In combination with finasteride, ketoconazole works even better, and the patients had a significant improvement in their condition. Combined treatment was more useful than finasteride alone, and no side effects were reported. However, there was no significant difference between ketoconazole and minoxidil as a side treatment. As such, it is considered a suitable alternative to minoxidil in these patients.

And one of the first studies of ketoconazole for hair loss showed that treating patients with ketoconazole shampoo can lead to potential hair regrowth after 6 months, which increases as the treatment continues and plateaus after one year and 3 months. In comparison, patients who used shampoo with no medication at all remained stable and sometimes experienced a significant increase in the severity of their condition.

Should you choose to use a shampoo with ketoconozale, we recommend Hair Restoration Laboratories’ Professional Strength Hair Restore Shampoo.  It contains 1% ketoconozale along with numerous other ingredients that have been clinically proven to help prevent hair loss and promote hair growth. 

The present and future of ketoconazole treatment for alopecia

Currently, androgenetic alopecia is a health problem with significant psycho social consequences, and there is a need of established and alternative therapies for these patients. The clinical studies and animal research about ketoconazole for the treatment of alopecia always support its use in some way. 

The application of this alternative can be useful in patients with androgenetic alopecia and concomitant seborrheic dermatitis, primarily because ketoconazole has been described as a useful therapy against Malassezia infections. It can also be a safe alternative for women with androgenetic alopecia who are unable to use finasteride treatment or display limited results with minoxidil.

Still, to study ketoconazole in the treatment of androgenic alopecia, we still need more large-scale prospective studies to figure out the exact mechanisms by which ketoconazole promotes hair regrowth. In any case, the absence of side effects of topical ketoconazole makes it a useful candidate to use as an adjunctive therapy to treat male and female patients with androgenetic alopecia, and well designed, and large-scale studies are still necessary to evaluate its efficacy on the long-term.

HEALTH

How Efficient Is PRP Therapy for Chronic Pain?

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How Efficient Is PRP Therapy for Chronic Pain?

Lingering, debilitating, chronic pain has a cascade impact on your body and everyday life. To relieve pain, most patients and their physicians have resorted to opioid drugs, but the remedy has done more harm than good. Since the late 1990s, when drug manufacturers convinced doctors that opioids had no addictive properties, over 2M persons have become hooked on these painkillers, and almost 48,000 opioid-related overdose fatalities have been recorded. That statistic accounts for about 130 person’s daily, and the numbers do not seem to stop soon, but instead are rising even higher. Whereas drugs, when properly supplied and used, have a position in pain management, Dr. Garen Gajian of Pain & Anesthesia Care takes a different approach. Whenever possible, Dr. Gajian chooses interventional techniques that combine cutting-edge technology, nonpharmacological paths, and innovative procedures. One such effective technique is PRP therapy. Read on to discover how effective New Brunswick PRP Therapy is in addressing chronic pain.

How Does Your Body Deal With Pain?

When you get hurt, your body goes into self-healing mode and releases platelet cells to the wounded location right away. These platelet cells include important healing and growth factors that help to repair injured tissues. Moreover, these platelets call on stem cells within your body to help complete the healing process and alleviate swelling and discomfort.

How Does PRP Improve Your Body’s Pain-Relieving Capabilities?

Generally, PRP is a contemporary therapy that aids in the relief of pain by boosting your body’s natural healing mechanism. PRP operates much like your body’s own systems; it packs the wounded area with those all-essential platelets, while also speeding up the healing process by delivering the platelets to the targeted area quicker and in greater concentrations.

Dr. Gajian begins by extracting a small blood sample from your arm, just like any standard check-up. He then spins your blood at increased speeds in a centrifuge, separating blood rich in platelets from blood with low platelet quantities. After that, he uses a syringe to deliver the platelet-rich plasma blood to the wounded region, which is the root of your chronic pain. Now, all that is left is to wait for the platelets to do what they do best: neutralize your agony and start healing.

What Types Of Pain Does PRP Help With?

As PRP keeps providing immediate and lasting pain relief for various conditions, more applications are being discovered. Nonetheless, some of the conditions PRP therapy has proven effective with include:

§  ACL injuries

§  Sprained ligaments

§  Ankle sprains

§  Rotator cuff injuries

§  Plantar fasciitis

§  Osteoarthritis pain

§  Tendonitis

§  Arthritis

§  Back injuries

§  Spinal injuries

§  Neck injuries

§  Tennis elbow

§  Disc herniation

§  Post-surgical wounds

How Safe Is PRP Therapy?

The safety of PRP is maybe its most significant feature. PRP utilizes your blood; hence, there is virtually minimal chance of rejection and infection. Besides, there is very little downtime to deal with. Only a needle injection to draw the blood and inject the platelets is needed; hence, you can resume your schedule right away.

How Efficient Is PRP?

Everybody reacts to PRP in their unique way. Most persons enjoy instant pain alleviation and complete recovery within several weeks or months. As your body reacts to the treatment and your stem cells begin to regenerate, you should notice a considerable reduction in your pain.  

More significantly, platelet-rich plasma strives to repair the inherent problem that has been triggering your chronic pain to continue to live free of pain.

Ultimately, PRP therapy has numerous advantages over other standard pain relief procedures. Not only will you enjoy an accelerated healing process and reduced downtime, but also minimal post-procedure complications and enhanced mobility. To explore the benefits of this revolutionary pain solution and establish if it could work for you, call the Pain & Anesthesia Care office in New Brunswick, NJ office or book an appointment online today.

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HEALTH

 Effective Remedies for the Flu and Strep Throat Infections

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 Effective Remedies for the Flu and Strep Throat Infections

Having a runny nose might seem irritating and cause discomfort, and in the case of children, it may be tougher to handle the condition. This situation may bother you, but there are available flu & strep Sugar Land treatments to help you or your child recover from the infections and leave you feeling healthy again.

What is the difference between the flu and strep throat?

The flu is also known as influenza, an infection that affects your respiratory system; lungs, throat, and nose. The influenza virus transmits through tiny airdrops if a person who has the flu sneezes or coughs around you. Strep throat is an infection that causes scratchy, raspy, and itchy throat. The condition stems from a bacterium, Streptococcus pyogenes, a very highly transmissible bacteria. Strep throat is spread when droplets from a person who has the infection sneeze or cough. Surfaces with bacteria can also be a source of infection.

What are the symptoms of flu and strep throat?

Both infections can affect all ages, so if you or your loved one develop the following symptoms, you should visit your doctor. The symptoms may be:

·                     Sore throat

·                     Fever

·                     Swollen tonsils

·                     Headache

·                     Stuffy nose

You may also develop the symptoms but not have strep throat. The flu may feel a lot more like a common cold in its initial stages, but the flu comes on suddenly. The flu also feels much worse than a cold. If strep throat is not treated, it can lead to further complications like rheumatic fever or inflammation in the kidney. If the symptoms start worsening, you develop chest pains, seizures, or difficulty breathing; you should get immediate medical care.

How are flu and strep throat treated?

Your doctor may first have to conduct a comprehensive physical examination through tests to check for flu symptoms or strep throat. Both infections can use the Polymerase Chain Reaction (PCR) test because the test is quick to spot the strains of the infections. Your doctor may also request a COVID-19 test to rule out its possibility. If you happen to have any of the infections, you will need to start treatment. Your doctor may give you painkillers and antibiotics to help reduce the symptoms and lower the risk of spread. If your doctor says the infection is severe, you may have to take an antiviral to help you recover from the flu. You should take the medication with food to reduce nausea and vomiting. You may also adopt some remedies at home like:

·                     Drinking plenty of liquids to avoid dehydration and keep your throat moist

·                     Get enough rest to help your body fight off the infection

·                     Use honey to soothe your throat. But do not give honey if your child is younger than a year.

·                     Gargling with salty water

After a few days, you should feel better in your throat, and you should take your total dosage. Seek emergency services if you see no improvement after two days of medication.

If you suspect you have the flu or strep throat, visit St. Michael’s Elite Hospital to find out more about the infection, get proper treatment, or book your appointment online.

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HEALTH

Effective Treatments for Managing Chronic Kidney Disease

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Effective Treatments for Managing Chronic Kidney Disease

Kidney disease is a medical condition requiring urgent attention to prevent further progression. There is a chance that you can get an early diagnosis and treatment before it develops into chronic kidney disease or even further to kidney failure. Tsegaw E Egziti M.D is a specialized doctor who can help you create a treatment plan and manage your condition.

What is kidney disease?

Kidney disease is a chronic disease that gradually involves the kidney’s malfunctioning. There are two kidneys in the human body, and they are responsible for the filtration and elimination of waste products from the blood, disposing of them through urine. Therefore if your kidney is not working correctly, they may be unable to filter and control your blood pressure accurately. Chronic kidney disease may always begin without detectable signs and may develop into a final stage failure, a fatal state if dialysis is not done, or even a kidney transplant. You may have to be on treatments for the rest of your life if you develop chronic kidney disease. But there are treatments available for managing your symptoms.

What are the signs and symptoms of kidney disease?

The signs and symptoms may develop gradually as the damage increases slowly. This damage may cause your body to build up waste or fluid and cause problems. The severity of the loss of function may cause signs and symptoms such as:

·                     Nausea and vomiting

·                     Fatigue

·                     Little or frequent urination

·                     Swollen feet

·                     High blood pressure

You may develop other signs and symptoms as the disease progresses, and you must see a doctor. An early diagnosis may prevent further progression of the disease to kidney failure.

What are the available treatments for kidney disease?

Your doctor may first have to carry out a comprehensive evaluation and run tests to determine the severity of your condition. Once the diagnosis is through, your doctor will recommend the proper treatment for you. These treatments may include:

·                     Medications

Your doctor may recommend particular drugs to help control the complications and make your life comfortable. There may be medications to lower blood pressure, lower cholesterol levels, and reduce swelling. These medications will help increase kidney function.

You may develop a final stage kidney disease, and this may require other forms of treatment such as:

·                     Dialysis

It is an artificial removal of waste products and fluid from the blood when your kidney fails to perform. If it is hemodialysis, a machine will filter excess fluid and waste products from your body. Your doctor may pass a tube through your belly and fill your cavity with a solution to absorb the waste and liquid. Later, the solution drains from the body with the debris alongside.

·                     Kidney transplant

Your doctor may recommend surgical removal of your kidney and replacing it with a healthy one. A healthy transplant comes from a donor or the deceased. Once you have a successful transplant, you may need regular medications to prevent your body from declining the new kidney.

Find out more about kidney disease and treatments at Houston Kidney Specialists Center or visit the website to request your appointment.

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